TY - JOUR T1 - Trends and interaction of polypharmacy and potentially inappropriate prescribing in primary care over 15 years in Ireland: a repeated cross-sectional study JF - BMJ Open Y1 - 2015 A1 - Moriarty, F A1 - Hardy, C A1 - Bennett, K A1 - Smith, SM A1 - Fahey, T AB - Objectives To examine: (1) changes in polypharmacy in 1997, 2002, 2007 and 2012 and; (2) changes in potentially inappropriate prescribing (PIP) prevalence and the relationship between PIP and polypharmacy in individuals aged ≥65 years over this period in Ireland. Methods This repeated cross-sectional study using pharmacy claims data included all individuals eligible for the General Medical Services scheme in the former Eastern Health Board region of Ireland in 1997, 2002, 2007 and 2012 (range 338 025–539 752 individuals). Outcomes evaluated were prevalence of polypharmacy (being prescribed ≥5 regular medicines) and excessive polypharmacy (≥10 regular medicines) in all individuals and PIP prevalence in those aged ≥65 years determined by 30 criteria from the Screening Tool for Older Persons’ Prescriptions. Results The prevalence of polypharmacy increased from 1997 to 2012, particularly among older individuals (from 17.8% to 60.4% in those aged ≥65 years). The adjusted incident rate ratio for polypharmacy in 2012 compared to 1997 was 4.16 (95% CI 3.23 to 5.36), and for excessive polypharmacy it was 10.53 (8.58 to 12.91). Prevalence of PIP rose from 32.6% in 1997 to 37.3% in 2012. High-dose aspirin and digoxin prescribing decreased over time, but long-term proton pump inhibitors at maximal dose increased substantially (from 0.8% to 23.8%). The odds of having any PIP in 2012 were lower compared to 1997 after controlling for gender and level of polypharmacy, OR 0.39 (95% CI 0.39 to 0.4). Conclusions Accounting for the marked increase in polypharmacy, prescribing quality appears to have improved with a reduction in the odds of having PIP from 1997 to 2012. With growing numbers of people taking multiple regular medicines, strategies to address the related challenges of polypharmacy and PIP are needed. VL - 5 UR - http://bmjopen.bmj.com/content/5/9/e008656.full IS - 9 ER - TY - JOUR T1 - Interventions to Address Potentially Inappropriate Prescribing in Community-Dwelling Older Adults: A Systematic Review of Randomized Controlled Trials JF - Journal of the American Geriatrics Society Y1 - 2016 A1 - Clyne, B A1 - Fitzgerald, C A1 - Quinlan, A A1 - Hardy, C A1 - Galvin, R A1 - Fahey, T A1 - Smith, SM VL - 64 IS - 6 ER - TY - Generic T1 - Patient preferences for breast cancer referral: Development and pilot study. ICHAMS RCSI Dublin October 2014. Awarded 1st Prize Y1 - 2014 A1 - Aherne, Emma A1 - O'Brien, K A1 - Quinlan, A A1 - McDonnell, R A1 - Hardy, C A1 - Galvin, R A1 - Fahey, T ER - TY - Generic T1 - Interventions to address potentially inappropriate prescribing in primary care: a systematic review of randomised control trials. RCSI Research Day. March 2015 Y1 - 2015 A1 - Fitzgerald, C A1 - Clyne, B A1 - Quinlan, A A1 - Hardy, C A1 - Galvin, R A1 - Fahey, T A1 - Smith, SM ER - TY - Generic T1 - Trends in polypharmacy and prescribing appropriateness from 1997 to 2012. Health Services Research and Pharmacy Practice (HSRPP) Conference, Belfast, 16/17th April 2015. Frank Moriarty Awarded Best Oral Presentation Y1 - 2015 A1 - Moriarty, F A1 - Hardy, C A1 - Bennett, K A1 - Smith, SM A1 - Fahey, T ER - TY - Generic T1 - Trends and interaction of potentially inappropriate prescribing and polypharmacy over 15 years in Ireland: a repeated cross-sectional study. Society for Social Medicine 59th Annual Scientific Meeting 2-4th September 2015 Y1 - 2015 A1 - Moriarty, F A1 - Hardy, C A1 - Bennett, K A1 - Smith, SM A1 - Fahey, T ER - TY - Generic T1 - The rise and fall of potentially inappropriate prescribing: trends and interaction with polypharmacy over 15 years in Ireland. Society for Academic Primary Care 44th Annual Conference, University of Oxford, 8th July 2015 Y1 - 2015 A1 - Moriarty, F A1 - Hardy, C A1 - Bennett, K A1 - Smith, SM A1 - Fahey, T ER - TY - Generic T1 - Interventions to address potentially inappropriate prescribing in primary care: a systematic review of randomised control trials. Health Services Research & Pharmacy Practice (HSRPP) Conference April 2015 Y1 - 2015 A1 - Clyne, B A1 - Fitzgerald, C A1 - Quinlan, A A1 - Hardy, C A1 - Galvin, R A1 - Fahey, T A1 - Smith, SM ER - TY - Generic T1 - Interventions to address potentially inappropriate prescribing in primary care: a systematic review of randomised control trials Society for Social Medicine 59th Annual scientific Meeting 2-4 Sept 2015 Dublin Y1 - 2015 A1 - Clyne, B A1 - Fitzgerald, C A1 - Quinlan, A A1 - Hardy, C A1 - Galvin, R A1 - Fahey, T A1 - Smith, SM ER -